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Journal of Asian Natural Products Research Volume 10, 2008 - Issue 11
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Original Articles

Canthin-6-one alkaloids from Picrasma quassioides and their cytotoxic activity

Mei-Xiang Jiang School of Pharmaceutical Science, Central South University, Changsha, China
&
Ying-Jun Zhou School of Pharmaceutical Science, Central South University, Changsha, ChinaCorrespondence[email protected]
Pages 1009-1012 | Received 27 Nov 2007, Accepted 02 Jun 2008, Published online: 22 Nov 2008
 
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Abstract

A new alkaloid, 4,5-dimethoxy-10-hydroxycanthin-6-one (1), was isolated from the stem of Picrasma quassioides Bennet (Simaroubaceae) together with four known canthin-6-one alkaloids, 8-hydroxycanthin-6-one (2), 4,5-dimethoxycanthin-6-one (3), 5-hydroxy-4-methoxycanthin-6-one (4), and 3-methylcanthin-5,6-dione (5). Their structures were elucidated on the basis of spectroscopic data. The cytotoxic activity of the canthin-6-one alkaloids was evaluated using human nasopharyngeal carcinoma (CNE2) and human liver cancer (Bel-7402) cell lines. Among these isolates, compounds 1–4 exhibited significant cytotoxic activity against CNE2 cell line.

Acknowledgements

We would like to thank Hunan University for the measurements of NMR and MS spectra, and the XiangYa Hospital for the use of the Laboratory of cell culture.

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