An effective O-demethylation of some C₁₉-diterpenoid alkaloids with HBr–glacial acetic acid

Chun-Lan Zou Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, China

Hong Ji Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, China

Guang-Bo Xie Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, China

Dong-Lin Chen Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, China

Feng-Peng Wang Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, ChinaCorrespondence[email protected]

Abstract

The aconitine-type alkaloids talatisamine (1), 8,14-diacetyltalatisamine (11), and compound 3, the lycoctonine-type alkaloid deltaline (5), and the 7,17-seco C₁₉-diterpenoid alkaloids 7 and 9 were treated with HBr–glacial acetic acid to give useful O-demethylated derivatives 2, 2, 4, 6, 8, and 10 respectively in good to high yields (49–90%).

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 30472075) and the Excellent Ph.D. Dissertation Foundation of China (No. 200367).

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An effective O-demethylation of some C₁₉-diterpenoid alkaloids with HBr–glacial acetic acid

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An effective O-demethylation of some C₁₉-diterpenoid alkaloids with HBr–glacial acetic acid