Microbial transformation of bufotalin by Alternaria alternata AS 3.4578

Xiu-Lan Xin Biotechnology Application Center, Beijing Vocational College of Electronic Science and Technology, Beijing, 100029, China; School of Pharmaceutical Sciences, Dalian Medical University, Dalian, 116027, China

Li-Bin Zhan The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100083, China

Feng-Yun Li The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100083, China

Xiao-Chi Ma The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100083, ChinaCorrespondence[email protected]

Ke-Xin Liu The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100083, China

Jian Han Biotechnology Application Center, Beijing Vocational College of Electronic Science and Technology, Beijing, 100029, China

De-An Guo Biotechnology Application Center, Beijing Vocational College of Electronic Science and Technology, Beijing, 100029, China

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Abstract

The microbial transformation of a cytotoxic bufadienolide, bufotalin (1), was carried out. Three transformed products from 1 by Alternaria alternata were isolated. Their structures were characterized as 3-keto-bufotalin (2), 12β-hydroxyl-bufotalin (3), and 3-keto-12β-hydroxyl-bufotalin (4) based on the extensive NMR studies. Among them, 3 and 4 were new compounds with strong in vitro cytotoxic activities against HeLa cells.

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Acknowledgements

We thank the Youth Foundation (30701088) by National Natural Science Foundation of China and PHR (IHLB) for financial support.

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Microbial transformation of bufotalin by Alternaria alternata AS 3.4578

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Microbial transformation of bufotalin by Alternaria alternata AS 3.4578

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