A new sesquiterpenoid metabolite from Psilocybe samuiensis

Abstract

A novel 2,3-secoaromadendrane-type sesquiterpenoid metabolite, psilosamuiensin A (1), was isolated from the broth of Psilocybe samuiensis. The structure of psilosamuiensin A was established by spectroscopic data and its configurations were confirmed by single crystal X-ray crystallographic analysis. This is the first report of psilosamuiensin A found in the genus Psilocybes.

Keywords:

• Psilocybe samuiensis
• magic mushroom
• hallucinogenic mushroom
• sesquiterpene
• secoaromadendrane

Acknowledgements

We thank Higher Education Commission Grants for Graduate Dissertation for financial support. Department of Chemistry, Faculty of Science, Chulalongkorn University, the Rachadapiseksompoj Endowment, Chulalongkorn University, National Center of Excellence for Petroleum, Petrochemicals and Advanced Materials (NCE-PPAM) and the Thailand Research Fund (RTA4880008) are also gratefully acknowledged.