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Abstract
Two new Daphniphyllum alkaloids, 4,21-deacetyl-deoxyyuzurimine (1) and macropodumine L (2), together with the two known related alkaloids, have been isolated from the bark of Daphniphyllum macropodum Miq. The structures of the new compounds were elucidated on the basis of the detailed analysis of spectroscopic data, chemical method, and by comparison of the spectroscopic data with those of known compounds. Compounds 2 and 4 exhibited weak cytotoxicity against human carcinoma cell lines SMMC-7721 and HO-8910.
Acknowledgements
This research work was financially supported by the National Marine ‘863’ projects (Nos 2006AA09Z447, 2006AA09Z412, and 2007AA09Z447), Natural Science Foundation of China (Nos 30730108 and 20721003), STCSM projects (Nos 07XD14036 and 06DZ22028), and CAS Key Project (grant KSCX2-YW-R-18). We are grateful to Prof. Huang Cai-Guo of Second Military Medical University for the cytotoxic activity test.