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Original Articles

Microbial transformation of dehydroandrographolide by Cunninghamella elegans

, , , , , , & show all
Pages 187-191 | Received 08 Sep 2008, Accepted 11 Nov 2008, Published online: 14 Feb 2009
 

Abstract

The biotransformation of dehydroandrographolide (1) by Cunninghamella elegans was performed and four transformed products were obtained. Based on their extensive spectral data, the structures of these metabolites were identified as 3-oxo-dehydroandrographolide (2), 3-oxo-2β-hydroxy-dehydroandrographolide (3), 3-oxo-8β,17α-epoxydehydroandrographolide (4), 3,19-dihydroxy-7,11,13-ent-labdatrien-15,16-olide (5), respectively. Among them, products 35 are new compounds.

Acknowledgements

The authors thank Bureau of Science & Technology of Dalian City (2008J23JH042) and National Natural Science Foundation of China (No. 20576010) for financial support.

Notes

Additional information

Notes on contributors

Xiao-Chi Ma

1 Email: [email protected]

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