Abstract
The biotransformation of dehydroandrographolide (1) by Cunninghamella elegans was performed and four transformed products were obtained. Based on their extensive spectral data, the structures of these metabolites were identified as 3-oxo-dehydroandrographolide (2), 3-oxo-2β-hydroxy-dehydroandrographolide (3), 3-oxo-8β,17α-epoxydehydroandrographolide (4), 3,19-dihydroxy-7,11,13-ent-labdatrien-15,16-olide (5), respectively. Among them, products 3–5 are new compounds.
Acknowledgements
The authors thank Bureau of Science & Technology of Dalian City (2008J23JH042) and National Natural Science Foundation of China (No. 20576010) for financial support.
Notes
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