Total synthesis of (−)-talaumidin and (−)-galbelgin

Peng Xue Peking Union Medical College and Chinese Academy of Medical Sciences, Institute of Materia Medica, Beijing, China

Li-Ping Wang Peking Union Medical College and Chinese Academy of Medical Sciences, Institute of Materia Medica, Beijing, China

Xiao-Zhen Jiao Peking Union Medical College and Chinese Academy of Medical Sciences, Institute of Materia Medica, Beijing, China

Ying-Jun Jiang Peking Union Medical College and Chinese Academy of Medical Sciences, Institute of Materia Medica, Beijing, China

Qiong Xiao Peking Union Medical College and Chinese Academy of Medical Sciences, Institute of Materia Medica, Beijing, China

Zhi-Gang Luo Peking Union Medical College and Chinese Academy of Medical Sciences, Institute of Materia Medica, Beijing, China

Ping Xie Peking Union Medical College and Chinese Academy of Medical Sciences, Institute of Materia Medica, Beijing, ChinaCorrespondence[email protected]

Xiao-Tian Liang Peking Union Medical College and Chinese Academy of Medical Sciences, Institute of Materia Medica, Beijing, China

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Abstract

( − )-Talaumidin (1) and ( − )-galbelgin (2) have been synthesized via 4-pentenoic acid as a starting material with the overall yield of about 17.8 and 16.9%, respectively. The key steps include Evans asymmetry anti-aldol reaction, TBS protection, hydroboration, oxidation, Friedel–Crafts arylation, etc.

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Total synthesis of (−)-talaumidin and (−)-galbelgin

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Total synthesis of (−)-talaumidin and (−)-galbelgin

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