Four new alkaloid derivatives from Ligularia duciformis

Abstract

Four new alkaloids, named 1-(4′-methylpyridazin-5′-yl)butane-1,2,3,4-tetraol (1), 3,9-dimethyl-5-nitropyrido[3,2,1-ij]quinazoline-1,7-dione (2), N,N-di(1-imine-propanyl)propionamidine (3), and 2,7-bis(isopropylimino)-2H,7H-dicyclopentacyclooctene-4,9-diol (4), were isolated from the rhizomes of Ligularia duciformis. Their structures were elucidated by spectral analysis.

Keywords:

• Compositae
• Ligularia duciformis
• alkaloids

Acknowledgements

We are grateful to Dr Dong-jun Chen and Associate Professor De-Ran Xu of China Pharmaceutical University for NMR and ESI-MS spectra. This work was financially supported by the Natural Science Foundation of China (NSFC) for Prof. Mian Zhang (No. 30270157).