Three new milbemycin derivatives from Streptomyces bingchenggensis

Abstract

In the continuing study of the chemical compositions of the strain Streptomyces bingchenggensis, three new milbemycin derivatives, milbemycin α₃₁ (1), secomilbemycins C (2), and D (3), were isolated. Their structures were established on the basis of extensive spectroscopic analysis.

Keywords:

• new milbemycin α₃₁
• secomilbemycins C and D
• Streptomyces bingchenggensis

Acknowledgements

This research work was financially supported by the National Natural Science Foundation of China (Nos 30571234 and 30771427), the National Key Technology R&D Program (No. 2006BAD31B02), and the Outstanding Youth Foundation of Heilongjiang Province (No. JC200706).