Two new homoisoflavonoids from the fibrous roots of Ophiopogon japonicus (Thunb.) Ker-Gawl

Abstract

Two new homoisoflavonoids ophiopogonone D (1) and ophiopogonanone G (2) were isolated from the fibrous roots of Ophiopogon japonicus. The structures of these two compounds were determined on the basis of spectroscopic means including HR-ESI-MS, 1D, and 2D NMR experiments. The cytotoxic activities of 1 and 2 against Hela and Hep2 cells are described.

Keywords:

• Ophiopogon japonicus (Thunb.) Ker-Gawl
• homoisoflavonoids
• cytotoxicity
• Liliaceae

Acknowledgements

This research work was supported by the program for Changjiang Scholar and Innovative Team in University (No. 985-2-063-112). Thanks are also extended to Prof. Shanyi Qiao for NMR measurements and Dr Yujuan Li for activity test.