Stereoselective hydrogenation on the exocyclic and conjugated double bond of sesquiterpene lactones by Aspergillusversicolor D-1

Abstract

Aspergillus versicolor D-1 was employed to convert dehydrocostuslactone (1) and 3-hydroxy-1(10),3,11(13)-guaiatriene-12,6-olide-2-one (5) stereoselectively. The reactions occurring were specific hydrogenation on the exocyclic α,β-double bond of sesquiterpene lactones with excellent conversion. Products were identified by the analysis of their spectra such as UV, IR, MS, ¹H, ¹³C NMR, and NOESY, and the structure of one new compound was elucidated. The characteristic of the stereoselective hydrogenation was also discussed and suggested.

Keywords:

• Aspergillus versicolor D-1
• dehydrocostuslactone
• stereoselective hydrogenation