Asphorodin, a potent lipoxygenase inhibitory triterpene diglycoside from Asphodelus tenuifolius

Muhammad Safder International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan

Muhammad Imran International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan

Rashad Mehmood International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan

Abdul Malik International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, PakistanCorrespondence[email protected]

Nighat Afza Pharmaceutical Research Center, PCSIR Karachi Laboratories Complex, Karachi, 75280, Pakistan

Lubna Iqbal Pharmaceutical Research Center, PCSIR Karachi Laboratories Complex, Karachi, 75280, Pakistan

Mehreen Latif Pharmaceutical Research Center, PCSIR Karachi Laboratories Complex, Karachi, 75280, Pakistan

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Abstract

Asphorodin (1), a new diglycoside, has been isolated from the ethyl acetate-soluble fraction of Asphodelus tenuifolius. It showed significant inhibitory activity against the enzyme lipoxygenase in a concentration-dependent manner. The Lineweaver–Burk and Dixon plots indicated that the nature of inhibition was non-competitive.

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Asphorodin, a potent lipoxygenase inhibitory triterpene diglycoside from Asphodelus tenuifolius

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Asphorodin, a potent lipoxygenase inhibitory triterpene diglycoside from Asphodelus tenuifolius

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