Four new long-chain aliphatics from the feces of Trogopterus xanthipes

Abstract

Chemical investigation of Trogopterus feces has led to the isolation of four new long-chain aliphatics, including two new fatty alcohols, 8,15-nonacosanediol (1) and 6,13-nonacosanediol (2), one new fatty acid ester, dihexyl 7,7′-oxydiheptanoate (3), and one new ceramide, (2R)-2-hydroxy-N-[(2S,3S,4R,11E)-1,3,4-trihydroxydocos-11-en-2-yl]heneicosanamide (4). Their structures were elucidated by means of chemical and extensive spectroscopic analysis. Compound 3 exhibited moderate activity of antithrombin in vitro.

Keywords:

• Trogopterus feces
• fatty alcohol
• fatty acid ester
• ceramide
• antithrombin

Acknowledgements

This research was financially supported by 2006 Great Basic Science Research Project of Jiangsu College and University (No. 06KJA36022). We also thank Mr Dong-Jun Chen, Drs Er-Xin Shang and Shu-Lan Su for other helpful assistance.