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Original Article

Synthesis and α-glucosidase inhibitory activity of oleanolic acid derivatives

Original article

, , , &
Pages 20-29 | Received 16 Jul 2009, Accepted 09 Oct 2009, Published online: 01 Feb 2010
 

Abstract

Glucosidations of oleanolic acid (1) and its dihydroxy-olide derivatives (2) were carried out to provide eight glycosides. All synthesized compounds were evaluated by in vitro α-glucosidase inhibitory activity assay. 3-Acetyl dihydroxy-olide oleanolic derivative 15 showed the most potent inhibitory effect. Structure–activity relationships within these compounds are discussed.

Notes

Additional information

Notes on contributors

Shan Qian

1. 1. [email protected]

Jiao Hai Li

2. 2. [email protected]

Yu Wei Zhang

3. 3. [email protected]

Xin Chen

4. 4. [email protected]

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