Chemical constituents from the cell cultures of Saussurea involucrata

Ri-Dao Chen Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College (Key Laboratory of Biosynthesis of Natural Drugs, Ministry of Public Health & Key Laboratory of Bioactive Substances and Resources Utilization, Ministry of Education), Beijing, 100050, China; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, 110016, China

Jian-Hua Zou Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College (Key Laboratory of Biosynthesis of Natural Drugs, Ministry of Public Health & Key Laboratory of Bioactive Substances and Resources Utilization, Ministry of Education), Beijing, 100050, China

Jing-Ming Jia School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaCorrespondence[email protected]

Jun-Gui Dai Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College (Key Laboratory of Biosynthesis of Natural Drugs, Ministry of Public Health & Key Laboratory of Bioactive Substances and Resources Utilization, Ministry of Education), Beijing, 100050, ChinaCorrespondence[email protected]

Abstract

The chemical constituents of the cell cultures of Saussurea involucrata were systematically investigated, thus a new eudesmane-type sesquiterpene together with 14 known compounds was isolated. Among them, syringin is the main compound with an isolated yield of 0.3%. The new compound was characterized as 11βH-2α-hydroxy-eudesman-4(15)-en-12,8β-olide (1) on the basis of extensive spectroscopic data.

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Acknowledgements

The authors gratefully acknowledge the financial support for this work by Beijing Natural Science Foundation (Grant No. 7092070) and the Program for New Century Excellent Talents in University (Grant No. NCET-06-0155).

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Chemical constituents from the cell cultures of Saussurea involucrata

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