Water-soluble constituents from the bark of Elaeagnus pungens and their cytotoxic activities

Abstract

Three new water-soluble compounds, pungens A–C, along with four known compounds including two phenol glycosides, one secoiso-flavanol and one phenol ether, have been isolated from the bark of Elaeagnus pungens. Among them, pungen C (7) (200 μg/ml) was tested in SGC-7901 and BEL-7404 tumor cell lines, and showed moderate cytotoxic activity. The structures of the new compounds were elucidated on the basis of spectroscopic data and chemical evidence.

Keywords:

• Elaeagnus pungens
• phenols and phenol glycosides
• isopropyl alcohol glycoside
• cytotoxicity
• SGC-7901 cell line
• BEL-7404 cell line

Acknowledgements

This research was financially supported by the Fujian Natural Science Foundation (Grant Nos. 2006NZ0002C4, 2008J0073, and 2009N0016). We are grateful to the staff of the analytical group of Kunming Institute of Botany, Chinese Academy of Sciences for measuring the spectra.