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Journal of Asian Natural Products Research Volume 1, 1998 - Issue 2
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Biotransformation of Podophyllotoxin to Picropodophyllin by Microbes

Hong Zhu Guo School of Pharmaceutical Sciences, Beijing Medical University, Beijing, 100083, P.R. China; School of Pharmaceutical Sciences, Beijing Medical University, Beijing, 100083, P.R. China
,
De An Guo School of Pharmaceutical Sciences, Beijing Medical University, Beijing, 100083, P.R. China
,
Xue Yan Fei College of Traditional Chinese Medicine, Beijing Union University, Beijing, 100034, P.R. China
,
Ya Jun Cui College of Traditional Chinese Medicine, Beijing Union University, Beijing, 100034, P.R. China
&
Jun Hua Zheng School of Pharmaceutical Sciences, Beijing Medical University, Beijing, 100083, P.R. China
Pages 99-102 | Received 20 Mar 1998, Accepted 26 Mar 1998, Published online: 04 Oct 2006
 
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Abstract

Biotransformation of podophyllotoxin (PT) by several microbial species has been investigated. Among the fungi tested, it was found that Penicillium strains can isomerize PT to picropodophyllin (PPT) in 8% yield and other strains also transform the substrate into the same product but with lower yield.

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