Pilot Study for the Investigation of Personal Breathing Zone and Dermal Exposure Using Levels of Polycyclic Aromatic Compounds (PAC) and PAC Metabolites in the Urine of Hot-Mix Asphalt Paving Workers

Abstract

As part of the design of a comprehensive study of hot-mix asphalt paving workers to investigate the relative contribution of personal breathing zone and dermal exposures to polycyclic aromatic compounds, a two-part pilot (Phase I) was performed. The pilot study was important to examine the sources of exposure, the chemical nature of these exposures, and their biological relevance through analysis of biomarkers in urine. Existing, modified, and new sampling and analytical techniques, used in concert with each other, were evaluated to help design the full-scale study (Phase II).

Although subject numbers were limited, the air, dermal, and urine sampling, analytical results and field experience provided valuable guidance in the design and implementation of Phase II. An overview of methods used and developed from this study is provided. More details of those methods selected for Phase II are presented in complementary manuscripts. Results of Phase II will be the subject of future publications.

Key Words:

• asphalt paving
• dermal
• inhalation
• polycyclic aromatic compounds

ACKNOWLEDGMENTS

This study was sponsored by the National Asphalt Pavement Association (NAPA) and the State Asphalt Pavement Associations (SAPA). The partnership, including the National Institute for Occupational Safety and Health (NIOSH), the Harvard School of Public Health, the Boston University School of Public Health, PetroLabs Inc. and Heritage Research Group (HRG), appreciate the involvement of Milestone Contractors LP (the asphalt paving and concrete control group contractor) and would like to extend a special thanks to the workers for their cooperation during this study. Thanks to Deborah Sammons (NIOSH), Kit Peregrine, and Adam Redman (HRG) for their field expertise. Finally, thanks to Damon Carl for his manuscript review. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. Mention of company names and/or products does not constitute endorsement by the National Institute for Occupational Safety and Health.