An Efficient Synthesis of Polycyclic Heterocycles Containing Pyrazolo[3,4-f]quinoline or Benzo[h]indazolo[6,7-b][1,6]naphthyridine Under Catalyst-Free Conditions

Abstract

A three-component Domino reaction of aromatic aldehydes, 1H-indazol-6-amine and barbituric acid or 4-hydroxyquinolin-2(1H)-one is described, and gave polycyclic heterocycles containing [1,6]naphthyridine or pyrazoloquinoline analog in high yields under catalyst-free conditions, respectively.

Key Words:

• domino reaction
• benzoindazolonaphthyridine
• catalyst-free
• pyrazoloquinoline

Additional information

Funding

The authors are grateful to the National Natural Science Foundation of China (20802061), a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions, the National Innovative Entrepreneurial Training Programs for Undergraduates (201310320005, HXKY2013A006), and College Industrialization Project (JHB2012-31) of Jiangsu Province for financial support.