ABSTRACT
A novel and clean one-pot synthesis of spiro[chromeno[2,3-c]pyrazole-4,3′-indoline]-2′,5(6H)-diones via cyclocondensation reaction of isatins, 1,3-cyclohexadiones, and pyrazolone in aqueous media using SBA-Pr-SO3H (sulfonic acid-functionalized mesoporous silica) as an efficient heterogeneous solid acid catalyst was reported. The antimicrobial activities of synthesized compounds have been tested.
Acknowledgments
Authors are thankful to the Research Council of Alzahra University and University of Tehran for the financial support for this work.