Synthesis of 1′-Aryl-1,3′-bi-β-carbolines and Their Saturated Counterparts

ABSTRACT

1-Aryl-β-carboline-3-carbaldehyde building blocks have been used as the starting materials for the synthesis of novel bis-β-carboline derivatives. In the two-step synthesis the Pictet–Spengler reaction was used before the dehydrogenation of the polycyclic compound to the aromatic derivatives.

KEYWORDS:

• β-Carbolines
• dehydrogenation
• nitrogen heterocycles
• Pictet–Spengler reaction