Solvent-Free One-Pot Synthesis of 1,8-Dioxo-Decahydroacridines by a [Et₃NH][HSO₄] Catalyzed Multicomponent Reaction

ABSTRACT

[Et₃NH][HSO₄] has been used as an effective catalyst for one-pot, three-component condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione and ammonium acetate for the synthesis of 1,8-dioxo-decahydroacridines under solvent-free conditions. The present methodology offers several advantages, such as high yields, short reaction times, mild condition, and a recyclable catalyst with a very easy work-up.

KEYWORDS:

• Aromatic aldehyde
• multicomponent reaction
• solvent-free conditions
• [Et₃NH][HSO₄]
• 1,8-dioxo-decahydroacridines
• 5,5-dimethyl-1,3-cyclohexanedione

Funding

The authors are grateful to the Natural Science Foundation of Hubei Province (grant No. 2007ABA291) for financial support.