Synthesis of Benzo[4,5]imidazo[1,2-a]naphthyridine and Benzo[4,5]imidazo[2,1-a]isoquinoline Derivatives Catalyzed by CuI/L-Proline

GRAPHICAL ABSTRACT

ABSTRACT

The benzo[4,5]imidazo[1,2-a]naphthyridines and benzo[4,5]imidazo[2,1-a]isoq-uino lines were obtained via a one-pot domino reaction of 2-(2-bromophenyl)-1H-benzo[d]imidazoles and cyclic 1,3-dicarbonyl compounds in good yields. This copper-catalyzed procedure provided an efficient method for the synthesis of fused pentacyclic heterocycles containing a α-arylation of carbonyl reaction.

KEYWORDS:

• Benzimidazonaphthyridine
• benzimidazoisoquinoline
• α-arylation
• copper-catalyzed
• synthesis

Additional information

Funding

We are grateful to the Major Natural Science Foundation of Jiangsu Province (14KJA150004) and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions for financial support.