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Polycyclic Aromatic Compounds Volume 40, 2020 - Issue 2
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Original Articles

An Organocatalytic Newer Synthetic Strategy Toward the Access of Polyfunctionalized 4H-Pyrans via Multicomponent Reactions

Rathinam RameshDepartment of Chemistry, Periyar University, Salem, Tamil Nadu, IndiaView further author information
,
Jayaraj JayamathiDepartment of Chemistry, Periyar University, Salem, Tamil Nadu, IndiaView further author information
,
Chinnagoundar KarthikaDepartment of Chemistry, Periyar University, Salem, Tamil Nadu, IndiaView further author information
,
Jan Grzegorz MaleckiDepartment of Crystallography, University of Silesia, Szkolna, Katowice, PolandView further author information
&
Appaswami LalithaDepartment of Chemistry, Periyar University, Salem, Tamil Nadu, IndiaCorrespondence[email protected]
View further author information
Pages 502-515 | Received 02 Dec 2017, Accepted 16 Mar 2018, Published online: 12 Apr 2018
 
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GRAPHICAL ABSTRACT

ABSTRACT

An energy efficient, facile, and environmentally benign synthetic method to obtain pharmaceutically fortunate, diverse 4H-pyrans from frequently accessible aryl aldehydes, malononitrile, and dissimilar 1,3-diketoesters is described. The reactions took place smoothly at ambient temperature using 2-aminopyridine as a low-cost organocatalyst. The present domino strategy furnishes, the desired products in high yields with shorter reaction times. The structures of the o-nitro substituted skeletons were unambiguously confirmed by mono-crystal XRD.

Supplementary information

The Crystallographic data of compounds 4f and 4p have been deposited with the Cambridge Crystallographic Data Centre having the CCDC Nos. 1542238 and 1542698, respectively. A copy of 1H and 13C NMR spectra for synthesized compounds were attached.

Additional information

Funding

Financial assistance from Department of Science and Technology, New Delhi, India [Scheme No: DST/INSPIRE Fellowship/2012/690] is gratefully acknowledged.

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