DABCO: An Efficient Base Catalyst for a Short and Faster One-Pot Three-Component Synthesis of Highly Functionalized Cyclohexenones: 2-Oxo-N,4,6-triarylcyclohex-3-enecarboxamides

Abstract

DABCO (1,4-diaza-bicyclo[2,2,2]octane) was applied as an efficient catalyst for the one-pot three-component synthesis of highly functionalized cyclohexenones: 2-oxo-N,4,6-triarylcyclohex-3-enecarboxamides via the condensation between acetophenone/4-methylacetophenone, aromatic aldehydes, and acetoacetanilide in ethanol at ambient condition. This methodology has a number of advantages such as high yields, short reaction times, clean work-up (just simple filtration), and mild reaction conditions.

Keywords:

• Acetoacetanilide
• DABCO
• 2-oxo-N,4,6-triarylcyclohex-3-enecarboxamides

Acknowledgment

We gratefully acknowledge financial support from the Research Council of the University of Sistan and Baluchestan.