Synthesis of 5,8-Diaryl-5,7,8,9-Tetrahydropyrimido[5,4-e]Tetrazolo[1,5-a]Pyrimidin-6(4H)-One Derivatives Catalyzed by MNPs@SiO₂-Pr-AP as a New Efficient Reusable Nanomagnetic Catalyst

Abstract

Some novel 5,8-diaryl-5,7,8,9-tetrahydropyrimido[5,4-e]tetrazolo[1,5-a]pyrimidin-6(4H)-one derivatives are prepared via one-pot reaction of aromatic aldehydes, 2-aminotetrazole and cyanoacetamide using two different types of catalytic systems including nano-magnetic catalyst supported with functionalized 4-amino-pyridine silica (MNPs@SiO₂-Pr-AP) and NEt₃. The highlighting points of using MNPs@SiO₂-Pr-AP are easy purification, reusability of the catalyst, good yields of products with short time reactions compared with NEt₃.

Keywords:

• Aromatic aldehydes
• magnetic nano particle
• multi-component reactions
• nano catalyst
• pyrimidine derivatives

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.