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Polycyclic Aromatic Compounds Volume 41, 2021 - Issue 9
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Research Articles

Synthesis, Antimicrobial Evaluation and Molecular Docking of New Functionalized Bis(1,3,4-Thiadiazole) and Bis(Thiazole) Derivatives

Huda K. Mahmouda Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
,
Ashraf A. Abbasa Chemistry Department, Faculty of Science, Cairo University, Giza, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7061-9907
ORCID Icon &
Sobhi M. Gomhaa Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt;b Department of Chemistry, Faculty of Science, Islamic University in Almadinah Almonawara, Almadinah Almonawara, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0001-6744-7817
ORCID Icon
Pages 2029-2041 | Received 01 Nov 2019, Accepted 20 Dec 2019, Published online: 08 Jan 2020
 
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Abstract

Many bis-1,3,4-thiadiazoles 7, 10a,b, 13a-c and bis-thiazoles 16a-d, 19a-d were synthesized from reaction of bis(hydrazonoyl) chloride 4 with a series of methyl carbodithioate and thiosemicarbazone derivatives. Their antimicrobial activities were evaluated with six selected microorganisms. Some of the prepared derivatives showed higher antimicrobial activity than the reference used. Furthermore, molecular docking of the most active compound 10 b and the active site of target enzymes were studied using MOE 2014.010 software package.

Conflicts of interest

The authors declare no conflict of interest.

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