Regioselective Synthesis of Unsymmetrical 3-(Quinolin-3-yl)Pentane-1,5-Diones in the Aqueous Medium through Montmorillonite KSF Catalysis

Abstract

In the presence of heterogeneous catalyst Montmorillonite KSF (M-KSF) 2-chloro-3-formyl quinolines, 1 were successfully converted into regioselective 3-(quinolin-3-yl)pentane-1,5-diones, 3. A one-pot sequential reaction (aldol-condensation-Michael addition) of distinct acetophenones, 2 was efficient in an aqueous medium.

Keywords:

• Ambient temperature
• C-C bond formation
• easy work up and product separation
• montmorillonite KSF
• low catalyst loading

Acknowledgments

The authors thank VIT-SIF for providing FT-NMR, FT-IR facilities and IIT Madras for HRMS facility.