Pd₂dba₃/P(t-Bu)₃H.BF₄/Cy₂NMe Catalyzed Heck Coupling in Synthesis of 3-Alkenyl-1H-Isochromen-1-Ones

Abstract

An efficient catalytic system comprising of Pd₂dba₃/P(t-Bu)₃H.BF₄/Cy₂NMe –for the Heck coupling in the synthesis of 3-alkenyl isochromen-1-ones, 3 has been developed. Air stable alkyl phosphonium salt, [(t-Bu)₃Ph]BF₄ was found to be vital for the activation of 3- chloroisochromen-1-ones, 1 in regio-selective Heck coupling reactions. The technique has additionally been reached out to typharin, penicilisorin and artemidin analogs.

Keywords:

• Heck reaction
• novel isocoumarins
• regio-selective
• Synthetic methods

Acknowledgements

The authors wish to express their gratitude to the Vellore Institute of Technology, Vellore, India for their support and facilities and SIF-VIT for their support of NMR, GCMS and IR. CHNS facilities .

Disclosure statement

No potential conflict of interest was reported by the author(s).