Facile Synthesis of Xanthenesdiones and Acridinediones through TEMPO/CuCl₂ Catalyzed Aerobic Oxidation of Benzyl Alcohols and Cyclization with Cyclohexane-1,3-Dicarbonyl Compounds

Abstract

A series of xanthenediones, 3 were synthesized from benzyl alcohols, 1 via TEMPO/CuCl₂ catalyzed aerobic oxidation, and sequential cyclization with cyclohexane-1,3-dicarbonyl compounds has been achieved. Similarly, the acridine-diones, 5 were obtained using a similar strategy from various benzyl alcohols. The strategy offers a simple experimental procedure, ease of access, within short reaction period, without the use of any hazardous solvents, and expensive chemicals.

Graphical Abstract

Keywords:

• Facile synthesis
• Cyclization reaction
• Metal-free synthesis
• Ambient temperature
• Easy work up and short reaction time

Acknowledgments

Thankful to Sophisticated instrumentation facility SIF-VIT for providing NMR, GC-MS FT-IR and other instrumentation