ZnFe₂O₄ Nano-Catalyzed One-Pot Multi-Component Synthesis of Substituted Tetrahydropyranoquinoline under Neat Ultrasonic Irradiation

Abstract

ZnFe₂O₄ nano-catalyzed facile synthesis of tetrahydropyranoquinoline derivatives (4a–f) via one-pot multi-component Povarov’s inverse-electron-demand hetero Diels–Alder reaction of substituted aromatic aldehyde (1), aromatic amine (2) with dihydrofuran (3) under ultrasonic irradiation. This may be helpful to society to get more active pharmaceutical ingredients. In the present study, a series of tetrahydroquinoline (4a–f) were synthesized and confirmed with several spectral characterization techniques. Synthetic approach of present research toward the synthesis of THQ was significantly shown that ZnFe₂O₄ plays a vital role in highly efficient, eco-friendly, recyclable heterogeneous nano-catalysts. This resulted in enhancing reaction rate, solvent-free reaction, easy to carry, simple isolation, and high yielded product.

Keywords:

• Neat condition
• Povarov’s reaction
• THQ
• ultrasonic irradiation
• ZnFe₂O₄

Acknowledgments

One of the authors Dr. Megha Rai is grateful to UGC, New Delhi, India for financial assistance in the form of major research project F. No. 42-393/2013 (SR).

Disclosure statement

The authors confirm that this article content has no conflict of interest.