Green Synthesis, Molecular Docking, In Silico ADME and Biological Evaluation of Methoxy Substituted 1,5-Benzodiazepines as Potential Antioxidant, Anti-Inflammatory, and Antidiabetic Agents

Abstract

Present work involves the green and environmentally benign synthesis of 1,5-benzodiazepines using iodine as a catalyst and PEG-400 as a green solvent at room temperature that gives an excellent yield of products. All the synthesized compounds were screened for their anti-inflammatory, antioxidant, and antidiabetic activity. All the synthesized compounds showed excellent antioxidant activity against DPPH and H₂O₂ radicals as compared to standard ascorbic acid and even more than standard for SOR and NO radicals. Compound 5h showed the highest % anti-inflammatory activity i.e., 80.73% among the series that was comparable to standard diclofenac sodium whereas compound 5d showed the highest antidiabetic activity i.e., 60.46% which was found potent as compared to standard acarbose.

Keywords:

• Antidiabetic
• anti-inflammatory
• antioxidant
• benzodiazepine
• ecofriendly
• orthophenylene diamine