PO₃H₂-Functionalized Fe₃O₄@SiO₂ Core–Shell as an Efficient and Magnetic Nanocatalyst for the Preparation of Dihydropyrimidinones via Biginelli Condensation

Abstract

Fe₃O₄@SiO₂ phosphonic acid nanoparticles are prepared to perform as a new and reusable acid catalyst for the one-pot synthesis of Biginelli products. One of the unique advantages of the catalyst is its simple and convenient synthesis, and that it is certified based on the results of FT-IR, XRD, TGA, TEM, SEM, EDX and VSM analysis. The catalyst may be recovered from the reaction mixture through the application of an external magnet and was found to be capable of repeated reuse without significant loss of activity.

Keywords:

• Biginelli condensation
• dihydropyrimidinone
• Fe₃O₄@SiO₂
• nanoparticle
• phosphonic acid

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors gratefully acknowledge the Razi University Research Council for support of this work.