KF/Clinoptilolite@MWCNTs Nanocomposites Promoted a Novel Four-Component Reaction of Isocyanides for the Green Synthesis of Pyrimidoisoquinolines in Water

Abstract

In this research the preparation of pyrimidoisoquinoline derivatives were performed by using four-component reactions of 4-aminocumarin, isocyanides, phthalaldehyde and ammonium acetate in the presence of catalytic amounts of KF/CP@MWCNTs NCs as a high performance catalyst in water at room temperature. In addition, because of having two acidic hydrogen we decide that investigate antioxidant activity of synthesized pyrimidoisoquinoline derivatives by DPPH radical trapping and reducing power of ferric ion experiments. In addition, the Gram-positive and negative bacteria disk diffusion research is used for the confirmation of antimicrobial power of some prepared pyrimidoisoquinolines. The outcomes of disk diffusion experiment showed that these compounds resisted the growth of bacteria. Our procedure has a few benefits relative to the reported method such as good rate of reaction, high efficiency, and simple removal of catalyst from mixture of reaction.

Highlights

• Multicomponent reactions (MCRs) are more interesting type of reaction due to mixing three or more reactants in one-pot and generating one product and economically useful and environmentally secure than to multi-step methods.

• Carrying out synthesis of organic compounds in water media is very interesting because of water is cheap solvent, more available with high amounts.

Keywords:

• 4-Aminocumarin
• DPPH radical trapping
• KF/CP@MWCNTs NCs
• pyrimidoisoquinoline

Acknowledgments

We gratefully acknowledge from Payame Noor University, Tehran, Iran because of spiritual support.

Disclosure statement

There are no conflicts of interest.