Microwave Irradiated Targeted Synthesis of Pyrrolobenzodiazepine Embrace 1,2,3-Triazole by Click Chemistry Synthetic Aspect and Evaluation of Anticancer and Antimicrobial Activity

Abstract

A new series of pyrrolobenzodiazepine derivatives containing 1,2,3-triazoles moiety has been designed and developed via Cu(I)-catalyzed azide-alkyne cycloaddition reaction, click chemistry synthetic aspect under microwave irradiation. The reaction has been curtained in diverse azide derivatives, solvent ratio, and catalyst for different time duration. The reaction has been studied with different azide substrate scope and proposed reaction mechanism has also been projected. Synthesized compounds also screening for in vitro anticancer activity and antimicrobial activity.

 

Keywords:

• Anticancer
• antimicrobial
• click chemistry
• pyrrolobenzodiazepine
• 1,2,3-triazole

Acknowledgment

The authors are thankful to the Department of Chemistry, Saurashtra University and Department of Chemistry, School of Science, RK University (Rajkot) for providing laboratory facilities and National Facility for Drug Discovery (NFDD) for providing all spectral data.

Disclosure statement

No potential conflict of interest was reported by the authors.