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Abstract
The aim of this research is the study of hexyltriphenylphosphonium bromide (HTPB) ionic liquid as a bifunctional promoter (solvent and catalyst) in the presence of cerium(IV) ammonium nitrate as a single electron oxidant for the Michael reaction at room temperature and solvent-free conditions. A novel, one-pot and environmentally benign the process to achieve the chemoselective of 2-(3-oxo-1,3-diarylpropyl)malononitrile derivatives instead of 2-(1,3-diarylallylidene)malononitriles using a three-component reaction involving acetophenone derivatives, various aromatic aldehydes and malononitrile was developed. This protocol is simple and provides biologically interesting products in good yields, short reaction times at ambient conditions without the need for using volatile solvents. The remarkable feature of this method is the chemoselectivity of its which makes this protocol effective and distinctive.
Graphical Abstract
Acknowledgments
Research reported in this publication was supported by Elite Researcher Grant Committee under award number (983991) from the National Institutes for Medical Research Development (NIMAD), Tehran, Iran and we gratefully acknowledge financial support from the Research Council of University of Medical Sciences, Kermanshah.
Disclosure statement
No potential conflict of interest was reported by the authors.