Multicomponent Synthesis of Pyrano (3, 2-c) Quinolone Fused Spirochromenes

Abstract

A multicomponent pathway has been described for the synthesis of novel pyrano (3,2-c) quinolone fused spirochromenes by piperidine catalyzed reaction between isatins, phenyl (or alkyl) sulfonyl acetonitrile and 4-hydroxy-N-methylquinoline-2-one. Decent yields coupled with easy isolation of the products and avoidance of conventional purification methods are the noteworthy merits of the developed protocol.

Keywords:

• 4-hydroxy-N- methylquinolin-2–one
• Isatin
• phenylsulfonyl acetonitrile
• piperidine
• multicomponent reactions
• spirochromenes

Acknowledgements

I acknowledge my sincere thanks to my research supervisor Prof. U. V. Desai for his continuing support and Shivaji University, Kolhapur (MS), India.

Disclosure statement

No potential conflict of interest was reported by the authors.