Efficient Green Chemistry Approach for the Synthesis of 1,2,3-Triazoles Using Click Chemistry through Cycloaddition Reaction: Synthesis and Cytotoxic Study

Abstract

Herein, we reported the synthesis of diverse N-(substituted phenyl)-2-(4-((dibenzylamino)methyl)-1H-1,2,3-triazol-1-yl)acetamide (6a–6j) through a green chemistry approach using water and eco-friendly catalysts using copper catalyzed click chemistry approach. The optimization of the reaction toward the greener way was discussed through applying the choline azide and ecological suitable solvent/reagent systems. The biological potency of the adducts was described against NCI-60 cancer cell lines in nine cancer panels and four scaffolds with halogens as phenyl ring substituents were found to be most active with negative GI₅₀ values.

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Keywords:

• Green synthesis approach
• click chemistry
• 1,2,3-triazoles
• methylene-linkers
• NCI-60 cell-line cancer study

Acknowledgments

We are thankful to the School of Science RK University, Rajkot for their great support in the laboratory and library facility. The authors are also thankful to NFDD “Center of Excellence”, Rajkot for instrumental support. Sincere thanks to the National Cancer Institute (NCI-NIH) for the anticancer screening.

Disclosure statement

The authors declare that there is no conflict.