Preparation and Characterization of Co (II) Supported on Modified Magnetic Fe₃O₄ Nanoparticles and Its Application as Catalyst for the Synthesis of 2-Amino-3-Cyanopyridines

Abstract

In this study, the surface of magnetic nano-Fe₃O₄ NPs was functionalized with melamine-imidazole groups to synthesize a novel heterogeneous support (Fe₃O₄@SiO₂@Si(CH₂)₃NH@CC@Im). Then, cobalt (II) acetate was added to the prepared support and, finally we used Fe₃O₄@SiO₂@Si(CH₂)₃NH@CC@Im@Co in order to construct 2-amino-3-cyanopyridines from the reaction of aldehydes, acetophenones, malononitrile and ammonium acetate. Synthesis of 2-amino-3-cyanopyridines was achieved in one pot operation by utilizing a simple set of readily available starting materials in excellent product yields with short reaction time. Furthermore, the prepared green heterogeneous catalyst can be recycled and recovered six times.

Keywords:

• 2-Amino-3-cyanopyridine
• Fe₃O₄ NPs
• cobalt
• magnetic

Acknowledgments

The authors would like to thank Bu-Ali Sina University, Center of Excellence Developmental of Environmentally Friendly Methods for Chemical Synthesis (CEDEFMCS) for financial supporting of this research.

Disclosure statement

No potential conflict of interest was reported by the authors.