Synthesis, Biological Evaluation, and Molecular Docking of New Benzimidazole-1,2,3-Triazole Hybrids as Antibacterial and Antitumor Agents

Abstract

A new series of benzimidazole-1,2,3-triazole hybrids have been successfully accomplished by the Click chemistry of different aromatic azides and propargylated benzimidazole (4). The structural confirmations of the molecules were done by NMR, mass spectrometry, IR, and other techniques. All the newly synthesized compounds were tested for their antibacterial potentialities against two Gram-positive and two Gram-negative bacterial strains. The antibacterial results displayed comparable activity of two compounds (7) and (9) with the standard drug against S. aureus and S. epidermidis. The anticancer results showed that compounds (6, 7, 10, and 14) were more promising than tamoxifen toward MCF-7 cells. Whereas, compound (6) was the most potent molecule with IC₅₀ 3.23, 6.56, and 5.35 μM toward MCF-7, HepG2, and HCT-116 cell lines, respectively. The molecular docking showed that the synthesized molecules 6, 7, 10, and 14 with promising cytotoxicity displayed similar interaction like erlotinib with EGFR protein. These results suggest that these benzimidazole derivatives are promising lead molecules for chemotherapeutics and microbial infections.

Keywords:

• Benzimidazole
• Click Chemistry
• 1,2,3-triazole
• anticancer
• antimicrobial
• molecular docking

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Acknowledgments

Al-Baha University is greatly acknowledged for the facilities provided to accomplish this work.

Disclosure statement

No potential conflict of interest was reported by the authors.