Synergism of Ultrasound and Choline Hydroxide for the Synthesis of the Azlactone Derivatives

Abstract

A greener method for synthesizing azlactone has been described by using a highly efficient, selective, biodegradable and recyclable Choline hydroxide (ChOH) catalyst in an aqueous media. This approach has several advantages, including mild reaction conditions, high yields, short reaction time, and a simple set-up, making it a convenient and smart choice for Azlactone synthesis. Furthermore, the proposed methodology has the distinct advantage of not requiring the acetic anhydride, which is a corrosive and controlled ingredient.

Keywords:

• Aromatic aldehyde
• hippuric acid
• Choline hydroxide
• aqueous media
• ultrasonication

Acknowledgments

We are thankful to Dr. S. B. Bajaj, Principal, J.E.S. College, Jalna, India, for providing laboratory facilities and for his kind support in the completion of this work.

Disclosure statement

No potential conflict of interest was reported by the authors.