Lipase Catalyzed One-Pot Synthesis of 3-Methyl-4-(Hetero) Arylmethyleneisoxazole-5(4H)-Ones under Aqueous Conditions

Abstract

Present work reports an efficient and environmentally benign approach for the synthesis of isoxazole-5(4H)-ones derivatives using lipase as biocatalyst. The one-pot multicomponent reaction of aldehyde, ethyl acetoacetate, and hydroxylamine hydrochloride at room temperature gives a 3-methyl-4-(hetero) arylmethylene isoxazole-5(4H)-ones derivatives using water as a solvent. The present protocol has many advantages such as shorter reaction time, excellent yields of products, easy work-up procedure, wide substrate scope tolerance, economical, etc. Moreover, the catalyst (lipase) was recovered and can be reused (up to four to five cycles) without significant loss of its catalytic activity.

Graphical Abstract

Keywords:

• Aldehyde
• isoxazole
• lipase
• multicomponent
• one pot
• water

Disclosure statement

The authors declare no competing financial interest.

Authors’ contributions

The manuscript was written through the contributions of all authors. All authors have approved the final version of the manuscript.

Additional information

Funding

This article was funded by TEQIP III.