Fabrication and Characterization of a Novel and Efficient Zinc Nanomagnetic Catalyst for Multicomponent Synthesis of Heterocycles

Abstract

The zinc (II) complex supported on magnetic nanoparticles Fe₃O₄ as a novel and efficient magnetically recoverable catalyst (Fe₃O_4-Phenanthroline-Zn) was designed and characterized using the most common spectroscopic techniques including FT-IR spectroscopy, SEM, TEM, EDX, XRD, VSM, and ICP-OES. The Fe₃O₄-Phenantroline-Zn catalyst is shown to be efficient for the multicomponent synthesis of heterocycles including highly substituted piperidines and pyrano[2,3-d]pyrimidines. This system has many advantages, such as excellent level of reusability of magnetic catalysts, high yields, simplicity of separation of catalysts using an external magnet, environmental benignity and ease of handling. To the best of our knowledge, it is the first report on the utilization of zinc nanomagnetic catalyst for the multicomponent synthesis of highly substituted piperidines.

Graphical Abstract

Keywords:

• Zinc nanomagnetic catalyst
• Fe₃O₄-Phenanthroline-Zn
• Highly substituted piperidines
• Pyrano[2,3-d]pyrimidines
• Magnetic separation

Acknowledgement

This work was supported by the Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia [Project No. GRANT721].

Disclosure statement

No potential conflict of interest was reported by the author(s).