Abstract
Pyrazole category with all derivatives have well-known with biological and industrial applications. Pyrazole combined with other cycle (aliphatic or heterocycles) through one carbon atoms afforded spiropyrazoles. This spiropyrazoles characterized with biological importance as antitumor, analgesic, anti-inflammatory, vasodilation, aldosterone antagonistic, antimicrobial, phosphodiesterase, anabolic, androgenic, progestational, and salt-retaining activities. We interested in this review to collect and sort the spiropyrazoles according to their combined rings and illustrated the different methods of synthesis until the middle of 2021.
Acknowledgement
The authors would like to thank the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant Code: (22UQU4350477DSR11).
Disclosure statement
No potential conflict of interest was reported by the author(s).
Correction Statement
This article has been corrected with minor changes. These changes do not impact the academic content of the article.