Preparation of 2-Amino-4-Phenyl-4a,5,6,7-Tetrahydronaphthalene-1,3,3(4H)-Tricarbonitriles Using Prepared CuI Nanoparticles via Green Method by Berberis integerrima (Barberry) Extract

Abstract

In recent years, considerable attention has been paid to multi-component reactions due to the synthesis of desired products with therapeutic properties. Multi-component reactions are one of the most successful methods in increment of structure diversity and complex molecules through simple methods. They can provide effective, efficient, and feasible methods in pharmaceutical chemistry and modern complex compounds with structural diversity. Therefore, it has always been tried to prepare these compounds by using optimal methods and designing efficient and recyclable catalysts. Therefore, the attention to finding new environmentally friendly protocols as a vital issue for the production of metal nanoparticles as a catalyst is developing day by day. In this study, the preparation of copper iodide nanoparticles using barberry extract was investigated. Using barberry extract to prepare the catalyst is a cost-effective and environmentally friendly method. Barberry extract acted as a reducing agent for the synthesis of copper iodide nanoparticles. The structure of the nanoparticle was determined using scanning electron microscope (SEM), X-ray Powder Diffraction (XRD), Fourier transform infrared (FT-IR), and Energy Dispersive X-Ray Analysis (EDX). Then, the performance of the catalyst was evaluated in the synthesis of tetrahydronaphthalein1,3,3(4H)-carbonitrile. Green protocol, easy separation of the catalyst, and good to excellent yields are some of the benefits of the presented method.

Keywords:

• Copper iodide
• barberry extract
• multicomponent reactions
• tetrahydronaphthalein1,3,3(4H)-carbonitrile

Acknowledgments

The authors are grateful to University of Kashan for supporting this work.

Disclosure statement

No potential conflict of interest was reported by the author(s).