Microwave Assisted, H₃PW₁₂O₄₀ Mediated Green Synthesis, Crystal Structure, in-Vitro Anti-Inflammatory and Anti-Oxidant Investigation of Enaminoketones

Abstract

A simple microwave assisted tungstophosphoric acid (H₃PW₁₂O₄₀) catalyzed protocol was employed for the synthesis of versatile enaminoketones. The developed synthetic procedure is green, efficient and environmentally benign. Using this method, a series of enaminoketones were prepared from the condensation of dimedone and various amines. Further, the synthesized enaminoketones were evaluated for in-vitro anti-inflammatory activity by membrane stabilization method and anti-oxidant efficacy by radical scavenging method. The synthesized enaminoketones 3c, 3b and 3b, 3f showed reasonable anti-inflammatory as well as anti-oxidant activities respectively.

Graphical Abstract

Keywords:

• Microwave assisted synthesis
• tungstophosphoric acid
• dimedone
• amines
• anti-inflammatory activity
• anti-oxidant activity

Acknowledgment

The author ML acknowledges SIF-VIT for the support and Dr. Gokulnath from IISER, Kerala for single crystal XRD analysis.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors gratefully acknowledge Sichuan Youth Science and Technology Foundation [Grant no. 2017JQ0010]; Explorative Project [Grant no. G201601] of State Key Laboratory of Oil & Gas Reservoir Geology and Exploitation from Southwest Petroleum University; National High Technology Research and Development Program [Grant no. 2016ZX05053 and 2016ZX05014-005-007]; Key endowment Project of Educational Commission of Sichuan Province [Grant no. 16CZ0008] and China Postdoctoral Science Foundation [2019M650250], and the National Natural Science Foundation of China [Grant Nos. 41902303] for the support.