Design, Synthesis and Anticancer Evaluation of Novel Bis-Thiazol-1,2,4-Triazine Hybrids Contained 1,3,4-Oxadiazoles

Abstract

A new library of bis-thiazol-1,2,4-triazinehybrids having 1,3,4-oxadiazoles (10a–j) has been designed and synthesized. They were examined for their preliminary anticancer properties against four selected human cancer cell lines including SiHa (cervix), A549 (lung), MCF-7 (breast) and Colo-205 (colon) by using of MTT method and etoposide selected as a positive control. Most of the compounds displayed remarkable anticancer activities. Amongst, the five compounds 10a, 10b, 10c, 10d, and 10e demonstrated the most promising activity. Predominantly, compounds 10a and 10e possessed a higher potent inhibitory effect toward three cell lines.

Keywords:

• Tirapazamine
• 124-triazine
• Zibotentan
• 134-oxadiazole and anticancer activity

Acknowledgment

The authors are thankful to Department of Chemistry, Koneru Lakshmaiah Education Foundation and Laurus Labs Limitedfor constant encouragement in providing laboratory facilities and analytical data.

Disclosure statement

No potential conflict of interest was reported by the author(s).