Abstract
A highly efficient one-pot three-component protocol was devised for the synthesis of novel derivatives of ((phenylethlidene)hydrazinyl)thiazol-4(5H)one by the reaction of acetophenone derivatives, ethyl chloroacetate and thiosemicarbazide, in ethanol at room temperature in the presence of copper supported hydroxyapatite-encapsulated-γ-Fe2O3 (γ-Fe2O3@HAp@CPTMS@AT@Cu(ӀI)) as the new magnetically recyclable heterogeneous nanocatalyst. This novel protocol furnished the desired products in excellent yields (88–95%) and short reaction times (20–28 min). The structure and morphology of the synthesized catalyst were characterized by using various techniques such as FT-IR, Fe-SEM, EDX, XRD, TGA-DTA, and VSM.
Graphical Abstract
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Acknowledgments
The authors are thankful to the Research Council of University of Guilan for the partial support of this work.
Disclosure statement
No potential conflict of interest was reported by the authors