Molecular Docking Studies and Application of 6-(1-Arylmethanamino)-2-Phenyl-4H-Chromen-4-Ones as Potent Antibacterial Agents

Abstract

The present article depicts the synthesis of the series of 6-(1-arylmethanamino)-2-phenyl-4H-chromen-4-ones and their antibacterial activity against the S. aureus. 6-(1-arylmethanamino)-2-phenyl-4H-chromen-4-ones (1a–1n) were obtained via reductive amination reaction of 6-aminoflavone with various commercially available aldehydes. Synthesized compounds and 6-aminoflavone (1) were assessed for their antimicrobial activities against the S. aureus. 6-aminoflavone (1) was found to have an MIC of 2 µg/mL. The compounds with side chains 4-fluorobenzyl (1a), 4-chlorobenzyl (1b), 4-nitrobenzyl (1e), 4-methoxybenzyl (1g) and (quinolin-2-yl)methyl (1n) were found to have an MIC of 2 µg/mL. We have demonstrated that 6-(1-arylmethanamino)-2-phenyl-4H-chromen-4-ones are easily accessible via reductive amination reaction. These compounds are found to have antibacterial effect against S. aureus.

Keywords:

• Molecular docking
• 6-aminoflavone
• reductive amination
• antibacterial agent

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Acknowledgements

We thank Dr. S.R. Thopate (S. S. G. M. College Kopargaon) and Dr. D. K. Mhaske (M. J. S. College Shrigonda) for helpful discussion and suggestions. I acknowledge to Department of Science and Technology (DST-FIST) for their support.

Disclosure statement

No potential conflict of interest was reported by the author(s).