Ionic Liquid Catalyzed One-Pot Synthesis of 5-(4-Substituted-Phenyl)-1,3,4-Thiadiazole-2-Amines

Abstract

A highly efficient ionic liquid catalyzed protocol has been investigated for the synthesis of 5-(4-substituted-phenyl)-1,3,4-thiadiazole-2-amine derivatives from the cyclocondensation of diversely substituted aromatic carboxylic acid and thiosemicarbazide by using recyclable N-methylpyridiniumtosylate as an ionic liquid. Highly efficient, inexpensive, solvent and metal free, high step and atom efficiency and excellent yield (95%–98%) are remarkable features of present protocol.

Keywords:

• Aromatic acids
• ionic liquid-NMPYT
• thiosemicarbazide
• 2-aminothiadiazoles

Acknowledgement

We are thankful to the Principal, Vivekanand Arts, Sardar Dalipsingh Commerce and Science College, Aurangabad for supporting this research work by providing the Central research facility.

Disclosure statement

No potential conflict of interest was reported by the author(s).